Growth Differentiation Factor-9 Promotes the Growth, Development, and Survival of Human Ovarian Follicles in Organ Culture
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چکیده
منابع مشابه
P-52: Brain-Derived Neurotrophic Factor Promotes The Development of Human Ovarian Early Follicles during Growth In Vitro
Background Cryopreservation of ovarian cortex is increasingly used to preserve fertility before cancer therapy. Recently, studies show that Brain-derived neurotrophic factor (BDNF) may be involved in oocyte maturation. Brain-derived neurotrophic factor (BDNF) is member of neurotrophin family that has anti-apoptotic effects on nervous system. Recent researches show that it also plays key role in...
متن کاملBasic fibroblast growth factor promotes the development of human ovarian early follicles during growth in vitro.
STUDY QUESTION What is the effect of basic fibroblast growth factor (bFGF) on the growth of individual early human follicles in a three-dimensional (3D) culture system in vitro? SUMMARY ANSWER The addition of 200 ng bFGF/ml improves human early follicle growth, survival and viability during growth in vitro. WHAT IS KNOWN ALREADY It has been demonstrated that bFGF enhances primordial follicl...
متن کاملO-20: The Combination of Basic Fibroblast Growth Factor and Follicular Stimulating Hormone Promotes Human Follicle Development In Vitro Culture
Background Fertility preservation is an important part of scientific study in the field of reproductive medicine. Ovarian cryopreservation and in vitro follicles culture provide option for fertility conservation in older women or cancer patients. Basic fibroblast growth factor (bFGF) or FGF-2, is member of fibroblast growth factors family which play critical roles in cell migration proliferatio...
متن کاملP-173: Evaluation of The Follicular Growth after Mouse Ovarian Organ Culture in The Medium Supplemented with Growth Differentiation Factor-9B (GDF-9B)
Background: Growth differentiation factor -9B (GDF-9B) is an oocyte derived growth factor, this protein is essential for development of ovarian follicles and act mainly by binding to its receptor on the surface of granulosa cells. The effect of this factor on the growth of follicles in various developmental stages particularly primordial and primary follicles is unknown. The aim of this study w...
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The objective of this study was to determine the effects of GDF-9, IGF-I, and GH alone or combined on preantral follicle survival, activation and development after 1 and 7 days of in vitro culture. Either fresh (non-cultured) or cultured ovarian tissue was processed for histological and fluorescence analysis. For all media tested, the percent of normal follicles was greater when compared to min...
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ژورنال
عنوان ژورنال: Journal of Clinical Endocrinology & Metabolism
سال: 2002
ISSN: 0021-972X
DOI: 10.1210/jc.87.1.316